Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

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• 作者：Á ; ngel Marti虂nez-Castan虄eda ; Bele虂n Poladura ; Humberto Rodri虂guez-Solla ; Carmen Concello虂n ; Vicente del Amo
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：June 17, 2011
• 年：2011
• 卷：13
• 期：12
• 页码：3032-3035
• 全文大小：722K
• 年卷期：v.13,no.12(June 17, 2011)
• ISSN：1523-7052

文摘

The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reaction setup where stirring is not required.