Remote Optical Switch for Localized and Selective Control of Gene Interference

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• 作者：Somin Eunice Lee ; Gang Logan Liu ; Franklin Kim ; Luke P. Lee
• 刊名：Nano Letters
• 出版年：2009
• 出版时间：February 11, 2009
• 年：2009
• 卷：9
• 期：2
• 页码：562-570
• 全文大小：583K
• 年卷期：v.9,no.2(February 11, 2009)
• ISSN：1530-6992

文摘

Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.