Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization
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- 作者：Resham J. Banga ; Sai Archana Krovi ; Suguna P. Narayan ; Anthony J. Sprangers ; Guoliang LiuChad A. Mirkin ; SonBinh T. Nguyen
- 刊名：Biomacromolecules
- 出版年：2017
- 出版时间：February 13, 2017
- 年：2017
- 卷：18
- 期：2
- 页码：483-489
- 全文大小：541K
- ISSN：1526-4602
文摘
Small-sized (∼65 nm) doxorubicin (Dox)-loaded polymeric nanoparticles (PNPs) were modified with oligonucleotides to form colloidally stable Dox-loaded polymeric spherical nucleic acid (Dox-PSNA) nanostructures in biological media. The nucleic acid shell facilitates the cellular uptake of Dox-PSNA, which results in in vitro cytotoxicity against SKOV3 cancer cells.