Redox-Divergent Hydrogen-Retentive or Hydrogen-Releasing Synthesis of 3,4-Dihydroisoquinolines or Isoquinolines
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- 作者：Ke-Han He ; Wei-Dong Zhang ; Ming-Yu Yang ; Kai-Li Tang ; Mengnan Qu ; You-Song Ding ; Yang Li
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：June 17, 2016
- 年：2016
- 卷：18
- 期：12
- 页码：2840-2843
- 全文大小：432K
- 年卷期：0
- ISSN：1523-7052
文摘
A rare Ru-catalyzed highly selective synthesis of 3,4-dihydroisoquinolines or isoquinolines is accomplished via a redox-divergent hydrogen-retentive or hydrogen-releasing fashion. Notably, high cis-selectivity of 3,4-dihydroisoquinolines is achieved. Potential applications are shown by gram-scale reactions and very concise synthesis of N-containing polycyclic aromatic compounds. Primary mechanistic investigations indicate that the sequence of the major pathway involves Ru-catalyzed C–H activation, alkyne insertion, and subsequent 6π-electrocyclization.