Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
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- 作者：Songyun Xu ; Yongfeng Li ; Hanfa Zou ; Jieshan Qiu ; Zhong Guo ; and Baochuan Guo
- 刊名：Analytical Chemistry
- 出版年：2003
- 出版时间：November 15, 2003
- 年：2003
- 卷：75
- 期：22
- 页码：6191 - 6195
- 全文大小：140K
- 年卷期：v.75,no.22(November 15, 2003)
- ISSN：1520-6882
文摘
Analysis of low molecular weight compounds with matrix-assisted laser desorption/ionization time-of-flight massspectrometry (MALDI-TOFMS) has been developed byusing carbon nanotubes obtained from coal by arc discharge as the matrix. The carbon nanotube matrix functions as substrate to trap analytes of peptides, organiccompounds, and 
-cyclodextrin deposited on its surface.It has been found that carbon nanotubes can transferenergy to the analyte under laser irradiation, which makesanalytes well desorbed/ionized, and the interference ofintrinsic matrix ions can be eliminated. At the same time,the fragmentation of the analyte can be avoided. A goodsensitivity and excellent reproducibility of the spectrumsignals are achieved. It is believed that this work not onlywill open a new field for applications of carbon nanotubes,but also will offer a new technique for high-speed analysisof low molecular weight compounds in areas such asmetabolism research and characterization of naturalproducts.
-cyclodextrin deposited on its surface.It has been found that carbon nanotubes can transferenergy to the analyte under laser irradiation, which makesanalytes well desorbed/ionized, and the interference ofintrinsic matrix ions can be eliminated. At the same time,the fragmentation of the analyte can be avoided. A goodsensitivity and excellent reproducibility of the spectrumsignals are achieved. It is believed that this work not onlywill open a new field for applications of carbon nanotubes,but also will offer a new technique for high-speed analysisof low molecular weight compounds in areas such asmetabolism research and characterization of naturalproducts.