Antibacterial and Antiplasmodial Constituents of Beilschmiedia cryptocaryoides
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- 作者：Ferdinand Mouafo Talontsi ; Marc Lamsh枚ft ; Jonathan O. Bauer ; Andrianambinina A. Razakarivony ; Bakoli Andriamihaja ; Carsten Strohmann ; Michael Spiteller
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：January 25, 2013
- 年：2013
- 卷：76
- 期：1
- 页码：97-102
- 全文大小：325K
- 年卷期：v.76,no.1(January 25, 2013)
- ISSN：1520-6025
文摘
Four new beilschmiedic acid derivatives, cryptobeilic acids A鈥揇 (1鈥?b>4), and tsangibeilin B (5) have been isolated from the bark of Beilschmiedia cryptocaryoides collected from Madagascar. Their structures were elucidated using detailed spectroscopic and spectrometric methods. Cryptobeilic acid A (1) and tsangibeilin B (5) structures were confirmed by single-crystal X-ray diffraction analysis. Compounds 1鈥?b>5 displayed moderate antibacterial activity against Escherichia coli 6r3, Acinetobacter calcoaceticus DSM 586, and Pseudonamas stutzeri A1501, with the minimum inhibitory concentrations ranging from 10 to 50 渭M, respectively. In addition, the compounds exhibited antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and weak cytotoxicity against L6 cell lines.