Synthesis of 1-Amino-1H-Indenes via a Sequential Suzuki–Miyaura Coupling/Petasis Condensation Sequence

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• 作者：Vankudoth Jayaram ; Tailor Sridhar ; Gangavaram V. M. SharmaFabienne Berrée ; Bertrand Carboni
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：82
• 期：3
• 页码：1803-1811
• 全文大小：543K
• ISSN：1520-6904

文摘

An efficient and straightforward synthesis of 1-amino-1H-indenes is reported from 1,2-bis(boronates) via a sequential Suzuki–Miyaura coupling/Petasis cyclization reaction. Starting from the same monoboronic ester intermediates, an intermolecular version of this approach also afforded (Z)-α,β-unsaturated amino esters in moderate to good yields.