Expanding the Conformational Pool of cis--Sugar Amino Acid: Accommodation of 
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- 作者：Srivari Chandrasekhar ; Marepally Srinivasa Reddy ; Bathini Nagendra Babu ; Bharatam Jagadeesh ; Anabathula Prabhakar ; and Bulusu Jagannadh
- 刊名：Journal of the American Chemical Society
- 出版年：2005
- 出版时间：July 13, 2005
- 年：2005
- 卷：127
- 期：27
- 页码：9664 - 9665
- 全文大小：88K
- 年卷期：v.127,no.27(July 13, 2005)
- ISSN：1520-5126
文摘
Tendencies of forming stable helices of heterooligomers composed of alternating rigid cis-
-sugar amino acid and flexible -hGly motifs have been investigated, using a combination of molecular mechanics, CD, FT-IR, and NMR techniques. The results show that the solution structures of these oligomers exist as robust right-handed 14-helices. Here, we examine the role of conformationally rigid cis--sugar amino acid in preorganizing the conformation of -hGly to form the 14-helix. Our findings also show that a right-handed 14-helix can be formed with as few as four properly sequenced heterogeneous residues. These results represent the expansion of the conformational pool of sugar amino acid in the design of well-folded 14-helices, which can be used to develop -peptides endowed with biological activity.
-sugar amino acid and flexible -hGly motifs have been investigated, using a combination of molecular mechanics, CD, FT-IR, and NMR techniques. The results show that the solution structures of these oligomers exist as robust right-handed 14-helices. Here, we examine the role of conformationally rigid cis--sugar amino acid in preorganizing the conformation of -hGly to form the 14-helix. Our findings also show that a right-handed 14-helix can be formed with as few as four properly sequenced heterogeneous residues. These results represent the expansion of the conformational pool of sugar amino acid in the design of well-folded 14-helices, which can be used to develop -peptides endowed with biological activity.