文摘
The synthesis of all key fragments of the marine macrolide leiodelide A is described. The polyoxygenated northern subunit is derived from pan class="smallcaps">dpan>-xylose, while the southern subunit is rapidly assembled via an aldol reaction and Horner鈥揥adsworth鈥揈mmons olefination. This highly convergent approach will allow for rapid modification and assembly of several isomers of leiodelide A, which may be necessary considering the assignment of leiodelide B has been previously shown to be incorrect.