Synthesis of N-Arylindazoles and Benzimidazoles from a Common Intermediate

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• 作者：Brenda C. Wray ; James P. Stambuli
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：October 15, 2010
• 年：2010
• 卷：12
• 期：20
• 页码：4576-4579
• 全文大小：255K
• 年卷期：v.12,no.20(October 15, 2010)
• ISSN：1523-7052

文摘

A variety of N-aryl-1H-indazoles and benzimidazoles were synthesized from common arylamino oximes in good to excellent yields. The product selectivity depends upon the base used in the reaction, as triethylamine promoted the formation of benzimidazoles, whereas 2-aminopyridine promoted the formation of N-arylindazoles. This method is valuable to the synthetic community because both indazoles and benzimidazoles are prevalent in pharmaceuticals.