Palladium-Catalyzed Reactions of Enol Ethers: Access to Enals, Furans, and Dihydrofurans

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• 作者：Matthew G. Lauer ; William H. Henderson ; Amneh Awad ; James P. Stambuli
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 7, 2012
• 年：2012
• 卷：14
• 期：23
• 页码：6000-6003
• 全文大小：288K
• 年卷期：v.14,no.23(December 7, 2012)
• ISSN：1523-7052

文摘

The palladium-catalyzed oxidation of alkyl enol ethers to enals, which employs low loadings of a palladium catalyst, is described. The mild oxidation conditions tolerate a diverse array of functional groups, while allowing the formation of di-, tri-, and tetrasubtituted olefins. The application of this methodology to intramolecular reactions of alkyl enol ethers containing pendant alcohols provides furan and 2,5-dihydrofuran products.