Uracil Nucleosides with Reactive Group at C5 Position: 5-(1-Halo-2-sulfonylvinyl)uridine Analogues
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- 作者：Yong Liang ; Sazzad H. Suzol ; Zhiwei Wen ; Alain G. Artiles ; Logesh Mathivathanan ; Raphael G. Raptis ; Stanislaw F. Wnuk
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：March 18, 2016
- 年：2016
- 卷：18
- 期：6
- 页码：1418-1421
- 全文大小：334K
- ISSN：1523-7052
文摘
The transition-metal-catalyzed or radical-mediated halosulfonylation of 5-ethynyluridine provided (E)-(1-halo-2-tosylvinyl)uridines. These (β-halo)vinyl sulfones undergo efficient stereoselective addition–elimination with amines or thiols to provide Z-β-aminovinyl or E-β-thiovinyl sulfones tethered to the C5 position of the uracil ring.