A Fluorous-Tagged “Safety Catch” Linker for Preparing Heterocycles by Ring-Closing Metathesis

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• 作者：Catherine O’ ; Leary-Steele^† ; ; Christopher Cordier^† ; ; Jerome Hayes^‡ ; ; Stuart Warriner^† ; ; Adam Nelson*^† ;
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：February 19, 2009
• 年：2009
• 卷：11
• 期：4
• 页码：915-918
• 全文大小：204K
• 年卷期：v.11,no.4(February 19, 2009)
• ISSN：1523-7052

文摘

A fluorous-tagged “safety catch” linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitiates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only metathesis products. The synthesis of a range of heterocycles is described.