Arugosins G and H: Prenylated Polyketides from the Marine-Derived Fungus Emericella nidulans var. acristata
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- 作者：Ana Kralj ; Stefan Kehraus ; Anja Krick ; Ekaterina Eguereva ; Gerhard Kelter ; Martina Maurer ; Andreas Wortmann ; Heinz-Herbert Fiebig ; Gabriele M. Kö ; nig
- 刊名：Journal of Natural Products
- 出版年：2006
- 出版时间：July 2006
- 年：2006
- 卷：69
- 期：7
- 页码：995 - 1000
- 全文大小：108K
- 年卷期：v.69,no.7(July 2006)
- ISSN：1520-6025
文摘
The fungus Emericella nidulans var. acristata was isolated as an endophyte from a Mediterranean green alga. Cultivationof this fungus yielded two new compounds, arugosins G (1) and H (2), together with the known metabolites 3-9.Arugosins (1-4) are benzophenone derivatives, biosynthetically related to the xanthones 5, 6, and 9. The indole alkaloid7 displayed antitumor activity in a panel of 36 human tumor cell lines, exhibiting a mean IC50 value of 5.5 
g/mL inan in vitro survival and proliferation assay. Furthermore, compounds 3 and 4 showed moderate antitumor activity towardindividual tumor cell lines. None of compounds 1-8 exhibited any immunostimulatory activity assessed as the capacityto induce cytokines in PBMCs from healthy donors.
g/mL inan in vitro survival and proliferation assay. Furthermore, compounds 3 and 4 showed moderate antitumor activity towardindividual tumor cell lines. None of compounds 1-8 exhibited any immunostimulatory activity assessed as the capacityto induce cytokines in PBMCs from healthy donors.