Diastereoselective Intramolecular Friedel鈥揅rafts Cyclizations of Substituted Methyl 2-(1H-indole-1-carbonyl)acrylates: Efficient Access to Functionalized 1H-Pyrrolo[1,2-a]indoles

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• 作者：Dadasaheb V. Patil ; Marchello A. Cavitt ; Stefan France
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：November 4, 2011
• 年：2011
• 卷：13
• 期：21
• 页码：5820-5823
• 全文大小：762K
• 年卷期：v.13,no.21(November 4, 2011)
• ISSN：1523-7052

文摘

A general, catalytic method for the diastereoselective synthesis of functionalized 1H-pyrrolo[1,2-a]indoles via an intramolecular Friedel鈥揅rafts alkylation of N-acyl indoles is reported. Products were obtained in excellent yields (up to 98%) with high diastereoselectivities (up to >25:1 dr).