Enantioselective Organocatalytic Synthesis of Quaternary 伪-Amino Acids Bearing a CF3 Moiety

详细信息    查看全文

• 作者：Ralph Husmann ; Erli Sugiono ; Stefanie Mersmann ; Gerhard Raabe ; Magnus Rueping ; Carsten Bolm
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 4, 2011
• 年：2011
• 卷：13
• 期：5
• 页码：1044-1047
• 全文大小：752K
• 年卷期：v.13,no.5(March 4, 2011)
• ISSN：1523-7052

文摘

A highly enantioselective Friedel鈭扖rafts reaction catalyzed by a chiral phosphoric acid was developed. N-Boc-protected ethyl trifluoropyruvate imine was activated by 6 mol % of catalyst and reacted with a wide variety of indole derivatives to afford quaternary 伪-amino acids in excellent yields (up to 99%) and high enantioselectivities (up to 98:2 er).