Identification by 15N Refocused INADEQUATE MAS NMR of Intermolecular Hydrogen Bonding that Directs the Self-Assembly of Modified DNA Bases

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• 作者：Tran N. Pham ; Stefano Masiero ; Giovanni Gottarelli ; and Steven P. Brown
• 刊名：Journal of the American Chemical Society
• 出版年：2005
• 出版时间：November 23, 2005
• 年：2005
• 卷：127
• 期：46
• 页码：16018 - 16019
• 全文大小：101K
• 年卷期：v.127,no.46(November 23, 2005)
• ISSN：1520-5126

文摘

¹⁵N solid-state NMR refocused INADEQUATE spectra of two lipophilic deoxyguanosine derivatives unambiguously identify different intermolecular hydrogen-bonding arrangements that are indicative of either guanine ribbon or quartet self-assembly. The observation of guanine quartet formation in the absence of metal ions is a further example that challenges the accepted dogma that quartet formation requires metal ions.