Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class
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- 作者：Hai-Hua Lu ; Sergey V. Pronin ; Yevgeniya Antonova-Koch ; Stephan Meister ; Elizabeth A. Winzeler ; Ryan A. Shenvi
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：June 15, 2016
- 年：2016
- 卷：138
- 期：23
- 页码：7268-7271
- 全文大小：370K
- 年卷期：0
- ISSN：1520-5126
文摘
7,20-Diisocyanoadociane, a scarce marine metabolite with potent antimalarial activity, was synthesized as a single enantiomer in 13 steps from simple building blocks (17 linear steps). Chemical synthesis enabled identification of isocyanoterpene antiplasmodial activity against liver-stage parasites, which suggested that inhibition of heme detoxification does not exclusively underlie the mechanism of action of this class.