T-Muurolol Sesquiterpenes from the Marine Streptomyces sp. M491 and Revision of the Configuration of Previously Reported Amorphanes(1)

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• 作者：Ling Ding ; Roland Pfoh ; Stephan Rhl ; Song Qin ; Hartmut Laatsch
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：January 23, 2009
• 年：2009
• 卷：72
• 期：1
• 页码：99-101
• 全文大小：102K
• 年卷期：v.72,no.1(January 23, 2009)
• ISSN：1520-6025

文摘

Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3α-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC₅₀ of 6.7 μg/mL.