Directed Heterodimerization: Stereocontrolled Assembly via Solvent-Caged Unsymmetrical Diazene Fragmentation

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• 作者：Mohammad Movassaghi ; Omar K. Ahmad ; Stephen P. Lathrop
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：August 24, 2011
• 年：2011
• 卷：133
• 期：33
• 页码：13002-13005
• 全文大小：865K
• 年卷期：v.133,no.33(August 24, 2011)
• ISSN：1520-5126

文摘

A general strategy for the directed and stereocontrolled assembly of carbon鈥揷arbon linked heterodimeric hexahydropyrroloindoles is described. The stepwise union of complex amines in the form of mixed diazenes followed by photoexpulsion of dinitrogen in a solvent cage provides completely guided assembly at challenging C_sp³鈥揅_sp³ and C_sp³鈥揅_sp² connections.