A Spirodiepoxide-Based Strategy to the A-B Ring System of Pectenotoxin 4

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• 作者：Stephen D. Lotesta ; Yongquan Hou ; Lawrence J. Williams
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：March 1, 2007
• 年：2007
• 卷：9
• 期：5
• 页码：869 - 872
• 全文大小：91K
• 年卷期：v.9,no.5(March 1, 2007)
• ISSN：1523-7052

文摘

D=ol063087nn00002>A synthesis of a pectenotoxin 4 C1-C15 segment is reported. Suitable C1-C7 and C8-C15 segments were prepared, coupled, converted toI and the C3-hydroxy variant, and then cyclized. Key findings include the stereoselective conversion of the allene to the correspondingspirodiepoxide, oxidative cleavage of the p-methoxybenzyl ether, and cyclization of the spirodiepoxide to spiroketal II.