Boron-Catalyzed Direct Aldol Reactions of Pyruvic Acids

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• 作者：Doris Lee ; Stephen G. Newman ; Mark S. Taylor
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：December 3, 2009
• 年：2009
• 卷：11
• 期：23
• 页码：5486-5489
• 全文大小：181K
• 年卷期：v.11,no.23(December 3, 2009)
• ISSN：1523-7052

文摘

Interactions between pyruvic acids and diphenylborinic acid form the basis of an efficient, direct, boron-catalyzed aldol reaction that takes place in water at room temperature with low catalyst loadings. Both boronic and borinic acids function as catalysts, with the latter demonstrating particularly high activity. A wide range of aldehydes, including enolizable species, may be employed, delivering useful isotetronic acid derivatives in high yields.