Transition-Metal-Mediated Cascade Reactions: C,C-Dicyclopropylmethylamines by Way of Double C,C--Bond Insertion into B

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• 作者：Peter Wipf ; Corey R. J. Stephenson ; and Kazuo Okumura
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：December 3, 2003
• 年：2003
• 卷：125
• 期：48
• 页码：14694 - 14695
• 全文大小：65K
• 年卷期：v.125,no.48(December 3, 2003)
• ISSN：1520-5126

文摘

The organometallic multicomponent reaction of alkenyl zirconocene, alkynyl imine, and zinc carbenoid in the presence of dimethylzinc leads to novel C,C-dicyclopropylmethylamines. The formation of intermediate bicyclo[1.1.0]butanes represents the first synthetically useful example of a double C,C--bond insertion, and the increase in structural complexity from starting materials is highlighted by the formation of nine new C,C-bonds in the final product.