High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences

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• 作者：Andrew R. Bogdan ; Manwika Charaschanya ; Amanda W. Dombrowski ; Ying Wang ; Stevan W. Djuric
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：18
• 期：8
• 页码：1732-1735
• 全文大小：329K
• 年卷期：0
• ISSN：1523-7052

文摘

A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected substrates within minutes using acetonitrile as the solvent and without the use of acidic conditions or additional workups. Highly efficient, multistep reaction sequences in flow are also demonstrated wherein no extraction or isolation was required between steps.