Synthesis of Aryl Ketoamides via Aryne Insertion into Imides

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• 作者：Austin C. Wright ; Christopher K. Haley ; Guillaume Lapointe ; Brian M. Stoltz
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：18
• 期：12
• 页码：2793-2795
• 全文大小：260K
• 年卷期：0
• ISSN：1523-7052

文摘

An insertion of arenes into both imides and anhydrides via reactive aryne intermediates is presented. The reaction is performed under exceptionally mild conditions, and the corresponding ketoamide products are amenable to derivatization to deliver a variety of synthetically useful motifs such as quinolones, indoles, and ketoanilines.