New Insights into the HIFU-Triggered Release from Polymeric Micelles

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• 作者：Roel Deckers ; Agnes Paradissis ; Chris Oerlemans ; Marina Talelli ; Gert Storm ; Wim E. Hennink ; J. Frank W. Nijsen
• 刊名：Langmuir
• 出版年：2013
• 出版时间：July 30, 2013
• 年：2013
• 卷：29
• 期：30
• 页码：9483-9490
• 全文大小：307K
• 年卷期：v.29,no.30(July 30, 2013)
• ISSN：1520-5827

文摘

Continuous wave (CW), low frequency, high intensity focused ultrasound (HIFU) is a promising modality to trigger release of active compounds from polymeric micelles. The aim of the present study was to investigate whether high frequency CW as well as pulsed wave (PW) HIFU can induce the release of a hydrophobic agent from non-cross-linked (NCL) and core cross-linked (CCL) poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate] (mPEG-b-p(HPMAm-Lac_n)) micelles. It was shown that high frequency CW as well as PW HIFU was able to trigger the release (up to 85%) of a hydrophobic compound (i.e., nile red, NR) from NCL and CCL micelles. No changes in size distribution of the micelles after CW and PW HIFU exposure were observed and no degradation of polymer chain had occurred. We therefore hypothesize that the polymeric micelles are temporally destabilized upon HIFU exposure due to radiation force induced shear forces, leading to NR release on demand.