Macrocyclic Metal Complex–DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA
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- 作者：Jean-Louis H. A. Duprey ; James Carr-Smith ; Sarah L. Horswell ; Jaros?aw Kowalski ; James H. R. Tucker
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：January 27, 2016
- 年：2016
- 卷：138
- 期：3
- 页码：746-749
- 全文大小：316K
- ISSN：1520-5126
文摘
The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.