A New Catalyst for the Asymmetric Henry Reaction: Synthesis of 尾-Nitroethanols in High Enantiomeric Excess
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- 作者：James D. White ; Subrata Shaw
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：December 21, 2012
- 年：2012
- 卷：14
- 期：24
- 页码：6270-6273
- 全文大小：262K
- 年卷期：v.14,no.24(December 21, 2012)
- ISSN：1523-7052
文摘
A new chiral tetrahydrosalen ligand has been designed and synthesized from cis-2,5-diaminobicyclo[2.2.2]octane. The complex generated in situ by the interaction of the ligand with (CuOTf)2路C6H5CH3 was an efficient catalyst for the asymmetric Henry reaction, producing nitroaldol products in high yield and good stereoselectivity. Henry reactions catalyzed by this tetrahydrosalen-Cu(I) complex led to syntheses of 尾-adrenergic blocking agents (S)-toliprolol, (S)-moprolol, and (S)-propanolol.