Highly Enantioselective Total Synthesis of (+)-Isonitramine

详细信息    查看全文

• 作者：Yohan Park ; Young Ju Lee ; Suckchang Hong ; Myungmo Lee ; Hyeung-geun Park
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：February 3, 2012
• 年：2012
• 卷：14
• 期：3
• 页码：852-854
• 全文大小：720K
• 年卷期：v.14,no.3(February 3, 2012)
• ISSN：1523-7052

文摘

A new efficient enantioselective synthetic method of (+)-isonitramine is reported. (+)-Isonitramine was obtained in 12 steps (98% ee and 43% overall yield) from 未-valerolactam via enantioselective phase-transfer catalytic alkylation, Dieckman condensation, and diastereoselective reduction as key steps.