Divergent Syntheses of 2-Aminonicotinonitriles and Pyrazolines by Copper-Catalyzed Cyclization of Oxime Ester

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• 作者：Qifan Wu ; Yan Zhang ; Sunliang Cui
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1350-1353
• 全文大小：330K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

Copper-catalyzed cyclization of an oxime ester toward divergent heterocycle synthesis is reported. Oxime ester serves as an enamine precursor to cyclize with malononitrile and aldehydes for access to 2-aminonicotinonitriles in a one-pot reaction, while cyclizing with N-sulfonylimines leads to synthesis of pyrazolines.