Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors
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- 作者：Jiangtao Gao ; Mohamed M. Radwan ; Francisco Le贸n ; Olivia Reed Dale ; Afeef S. Husni ; Yunshan Wu ; Shari Lupien ; Xiaoning Wang ; Susan P. Manly ; Robert A. Hill ; Frank M. Dugan ; Horace G. Cutler ; Stephen J. Cutler
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：May 24, 2013
- 年：2013
- 卷：76
- 期：5
- 页码：824-828
- 全文大小：243K
- 年卷期：v.76,no.5(May 24, 2013)
- ISSN：1520-6025
文摘
Bioassay-guided fractionation of a fungus Neocosmospora sp. (UM-031509) resulted in the isolation of three new resorcylic acid lactones, neocosmosin A (2), neocosmosin B (3), and neocosmosin C (4). Three known resorcylic acid lactones, monocillin IV (1), monocillin II (5), and radicicol (6), were also isolated and identified. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analysis, mass spectrometric (ESIMS) data, and X-ray crystallography. Compounds 4鈥?b>6 show good binding affinity for the human opioid receptors. These findings have important implications for evaluating the potential psychoactive effects with this class of compounds.