Supramolecular Peptide/Surface Assembly for Monitoring Proteinase Activity and Cancer Diagnosis
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- 作者：Claire Soum ; Sandra Rubio-Albenque ; Suzanne Fery-Forgues ; G茅rard D茅l茅ris ; Mohamed-Anis Alouini ; Thomas Berthelot
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2015
- 出版时间：August 12, 2015
- 年：2015
- 卷：7
- 期：31
- 页码：16967-16975
- 全文大小：459K
- ISSN：1944-8252
文摘
Matrix metalloproteinases (MMP) are a family of proteolytic enzymes, the expression of which in a key step of tumor progression has recently been better defined. The overexpression of one or more MMPs is thus common among malignant tumors. It may characterize tumor progression and help predict its response to chemotherapy. Consequently, the development of a device for measuring MMP activities is an important challenge for diagnosis and prognosis. In this study, we describe an innovative supramolecular peptide/surface assembly for screening MMP activities. This sensor was used to discriminate various MMP activities and to distinguish between invasive and noninvasive cancerous cell suspensions. Our results confirm the proof-of-concept of a powerful tool for the determination of the tumor aggressiveness and a technical building block for future development of MMP lab-on-chip devices.