Synthesis of Water-Dispersible Fluorescent, Radio-Opaque, and Paramagnetic CdS:Mn/ZnS Quantum Dots: A Multifunctional Probe for Bioimaging
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- 作者：Swadeshmukul Santra ; Heesun Yang ; Paul H. Holloway ; Jessie T. Stanley ; and Robert A. Mericle
- 刊名：Journal of the American Chemical Society
- 出版年：2005
- 出版时间：February 16, 2005
- 年：2005
- 卷：127
- 期：6
- 页码：1656 - 1657
- 全文大小：112K
- 年卷期：v.127,no.6(February 16, 2005)
- ISSN：1520-5126
文摘
Ultra-small (3.1 nm) multifunctional CdS:Mn/ZnS core-shell semiconductor quantum dots (Qdots), which possess fluorescent, radio-opacity, and paramagnetic properties, have been shown here. To demonstrate in vivo bioimaging capability, a rat was administered endovascularly with Qdots conjugated with a TAT peptide. The labeling efficacy of these Qdots was demonstrated on the basis of the histological analysis of the microtome sliced brain tissue, clearly showing that TAT-conjugated Qdots stained brain blood vessels.