(9尾H)-Pimaranes and Derivatives from the Tuber of Icacina trichantha

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• 作者：Ming Zhao ; Monday M. Onakpa ; Bernard D. Santarsiero ; Wei-Lun Chen ; Karina M. Szymulanska-Ramamurthy ; Steven M. Swanson ; Joanna E. Burdette ; Chun-Tao Che
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2731-2737
• 全文大小：446K
• ISSN：1520-6025

文摘

New 17-nor-pimaranes (1, 2), (9尾H)-pimaranes (3, 4), and 17-nor-(9尾H)-pimarane (5) were isolated from the tuber of Icacina trichantha. The structures were elucidated based on spectroscopic and HRMS data. The absolute configurations of 3 and 5 were determined by single-crystal X-ray diffraction. Compound 5 possesses a unique 19,20-未-lactone moiety. Compound 3 showed cytotoxicity against MDA-MB-435 (human melanoma cancer) cells with an IC₅₀ value of 7.04 渭M. A plausible biogenetic pathway for compounds 1鈥?b>5 is proposed.