Antimycobacterial Labdane Diterpenes from Leucas stelligera

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• 作者：Roshan R. Kulkarni ; Ketaki Shurpali ; Vedavati G. Puranik ; Dhiman Sarkar ; Swati P. Joshi
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：October 25, 2013
• 年：2013
• 卷：76
• 期：10
• 页码：1836-1841
• 全文大小：252K
• 年卷期：v.76,no.10(October 25, 2013)
• ISSN：1520-6025

文摘

Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1鈥?b>4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using 1D and 2D NMR spectroscopic data and single-crystal X-ray crystallography of compound 1. Compounds 1鈥?b>4 exhibited selective antimycobacterial activity against Mycobacterium tuberculosis with IC₅₀ values in the range 5.02鈥?.80 渭g/mL.