文摘
Dietary intake studies of lower brominated diphenylethers (BDEs) have shown that fish and animal productsare important vectors of human exposure, but almost no dataexist for higher brominated BDEs. Therefore, the fate ofhepta- to decaBDEs was studied in lactating cows exposedto a naturally contaminated diet by analyzing feed,feces, and milk samples from a previous mass balancestudy of PCB. Tissue distribution was studied in one cowslaughtered after the experiment. BDE-209 was thedominant congener in feed, organs, adipose tissues, andfeces, but not in milk. In contrast to PCBs and lower brominatedBDEs, concentrations of hepta- to decaBDEs in adiposetissue were 9-80 times higher than in milk fat andthe difference increased with degree of bromination/logKow. The congener profiles in adipose tissue and feed differed;BDE-207, BDE-196, BDE-197, and BDE-182 accumulatedto a surprisingly greater extent in the fat compared to theirisomers, suggesting metabolic debromination of BDE-209to these BDEs. The results indicate that meat rather thandairy product consumption may be an important humanexposure route to higher brominated BDEs.