Generation of Geometrically Ordered Lipid-Based Liquid-Crystalline Nanoparticles Using Biologically Relevant Enzymatic Processing

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• 作者：Wye Khay Fong ; Stefan Salentinig ; Clive A. Prestidge ; Raffaele Mezzenga ; Adrian Hawley ; Ben J. Boyd
• 刊名：Langmuir
• 出版年：2014
• 出版时间：May 20, 2014
• 年：2014
• 卷：30
• 期：19
• 页码：5373-5377
• 全文大小：282K
• 年卷期：v.30,no.19(May 20, 2014)
• ISSN：1520-5827

文摘

High-symmetry lipid nanoparticles with internal bicontinuous cubic phase structure (cubosomes) are prepared from a simple emulsion containing a mixture of a nondigestible lipid (phytantriol) and a digestible short-chained triglyceride using enzymatic lipolysis of the incorporated short-chained triglyceride. The lipolytic products partition away from the nondigestible lipid, resulting in crystallization of the cubic-phase internal structure. Time-resolved small-angle X-ray scattering revealed the kinetics of the disorder-to-order transition, with cryo-transmission electron microscopy showing an absence of liposomes. The new approach offers a new 鈥渟ideways鈥?method for the generation of lipid-based nanostructured materials that avoids the problems of top-down and bottom-up approaches.