Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids

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• 作者：Simone Carradori ; Maria Concetta Gidaro ; Anél Petzer ; Giosuè Costa ; Paolo Guglielmi ; Paola Chimenti ; Stefano Alcaro ; Jacobus P. Petzer
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：November 30, 2016
• 年：2016
• 卷：64
• 期：47
• 页码：9004-9011
• 全文大小：571K
• ISSN：1520-5118

文摘

Naturally occurring flavonoids display a plethora of different biological activities, but emerging evidence suggests that this class of compounds may also act as antidepressant agents endowed with multiple mechanisms of action in the central nervous system, increasing central neurotransmission, limiting the reabsorption of bioamines by synaptosomes, and modulating the neuroendocrine and GABA_A systems. Due to their presence in foods, food-derived products, and nutraceuticals, we established their role and structure–activity relationships as reversible and competitive human monoamine oxidase (MAO) inhibitors. In addition, molecular modeling studies, which evaluated their modes of MAO inhibition, are presented. These findings could provide pivotal implications in the quest of novel drug-like compounds and for the establishment of harmful drug–dietary supplement interactions commonly reported in the therapy with antidepressant agents.