An Aldol Approach to the Synthesis of the EF Fragment of Spongistatin 1

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• 作者：Michael T. Crimmins ; Jason D. Katz ; Laura C. McAtee ; Elie A. Tabet ; and Steven J. Kirincich
• 刊名：Organic Letters
• 出版年：2001
• 出版时间：March 22, 2001
• 年：2001
• 卷：3
• 期：6
• 页码：949 - 952
• 全文大小：73K
• 年卷期：v.3,no.6(March 22, 2001)
• ISSN：1523-7052

文摘

A synthesis of the C29-C51 fragment of spongistatin 1, containing the E and F rings, has been completed. The approach relies on fourdiastereoselective aldol additions and an asymmetric glycolate alkylation to establish eight of the eleven stereogenic centers. The intactchlorodiene side chain was appended by a Lewis acid catalyzed addition of an allylstannane to an epoxy enol ether.

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