Incorporation and Characterization of a Mixing Elbow on the Pilot Plant Scale for a Mixing Sensitive Crystallization of an API

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• 作者：Utpal K. Singh ; Glenn Spencer ; Rich Osifchin ; Jose Tabora ; Omar A. Davidson ; and Charles J. Orella
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2005
• 出版时间：May 25, 2005
• 年：2005
• 卷：44
• 期：11
• 页码：4068 - 4074
• 全文大小：464K
• 年卷期：v.44,no.11(May 25, 2005)
• ISSN：1520-5045

文摘

A mixing elbow was, for the first time, characterized on the pilot plant scale using the FourthBourne Reaction to obtain a correlation for mixing time using the approach of Johnson andPrud'homme and Mahajan and Kirwan. The elbow was applied for a semicontinuous mixingsensitive crystallization of an API (Active Pharmaceutical Ingredient) on the pilot plant scaleto offer a means of controlling secondary nucleation and providing rapid mixing to eliminatelocal regions of high supersaturation. The application of the mixing elbow for the APIcrystallization resulted in a change in particle morphology in the form of single crystals ratherthan dense agglomerates that were observed in the absence of a mixing elbow.