Prorocentrol, a Polyoxy Linear Carbon Chain Compound Isolated from the Toxic Dinoflagellate Prorocentrum hoffmannianum

详细信息    查看全文

• 作者：Kohtaro Sugahara ; Yoshiaki Kitamura ; Michio Murata ; Masayuki Satake ; Kazuo Tachibana
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：May 6, 2011
• 年：2011
• 卷：76
• 期：9
• 页码：3131-3138
• 全文大小：991K
• 年卷期：v.76,no.9(May 6, 2011)
• ISSN：1520-6904

文摘

A polyoxy linear carbon chain compound, prorocentrol (1), was isolated from cultured cells of the dinoflagellate Prorocentrum hoffmannianum, which produces a polyether carboxylic acid, okadaic acid. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Compound 1 possesses 30 hydroxy groups, 1 ketone, and 8 double bonds on the C65-linear carbon chain. Its partial relative configuration was deduced by the proton鈭抪roton and long-range carbon鈭抪roton coupling constants, and compound 1 showed moderate cytotoxicity and antidiatom activity.