Brevisulcatic Acids, Marine Ladder-Frame Polyethers from the Red Tide Dinoflagellate Karenia brevisulcata in New Zealand
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- 作者：Rina Suzuki ; Raku Irie ; Yanit Harntaweesup ; Kazuo Tachibana ; Patrick T. Holland ; D. Tim Harwood ; Feng Shi ; Veronica Beuzenberg ; Yoshiyuki Itoh ; Steven Pascal ; Patrick J. B. Edwards ; Masayuki Satake
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：November 21, 2014
- 年：2014
- 卷：16
- 期：22
- 页码：5850-5853
- 全文大小：273K
- ISSN：1523-7052
文摘
The isolation and structural determination of new marine ladder-frame polyethers, brevisulcatic acids-1 (1) and -4 (2) are reported. Brevisulcatic acids were isolated from the dinoflagellate Karenia brevisulcata, which was identified as the causative species of a major red tide event in New Zealand in 1998. The ether ring composition and a 尾-hydroxy, 纬-methylene valeric acid side chain of 1 and 2 are common, but 2 has a 纬-lactone as the 5-membered A-ring while 1 is the seco acid analogue. Compound 2 has structural and bioactivity similarities to brevetoxin A.