Highly Stereoselective 1,4-Conjugate Addition of Organocopper Reagents to Methyl -D-Glucopyranoside Derivativ

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• 作者：Kiichiro Totani ; Takayuki Nagatsuka ; Ken-ichi Takao ; Shigeru Ohba ; and Kin-ichi Tadano
• 刊名：Organic Letters
• 出版年：1999
• 出版时间：November 4, 1999
• 年：1999
• 卷：1
• 期：9
• 页码：1447 - 1450
• 全文大小：148K
• 年卷期：v.1,no.9(November 4, 1999)
• ISSN：1523-7052

文摘

The 1,4-conjugate additions of a variety of organocopper reagents to some 4-O-crotonyl derivatives of methyl -D-glucopyranoside proceededwith a high level of diastereochemical induction to provide the adducts carrying a -substituted butanoic ester at C-4. The 1,4-conjugateaddition to a 6-O-crotonyl derivative afforded the adduct with reverse configuration at the -carbon to that obtained from the 4-O-crotonylderivatives.

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