Biocompatible Star Block Copolymer Hydrogel Cross-linked with Calcium Ions

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• 作者：Yoshiyuki Nakagawa ; Yuki Amano ; Satoshi Nakasako ; Seiichi Ohta ; Taichi Ito
• 刊名：ACS Biomaterials Science & Engineering
• 出版年：2015
• 出版时间：October 12, 2015
• 年：2015
• 卷：1
• 期：10
• 页码：914-918
• 全文大小：394K
• ISSN：2373-9878

文摘

Hydrogels cross-linked with calcium ions (Ca²⁺) have various potential medical applications. A star block copolymer with a dendritic polyester (DPE) core and double hydrophilic block copolymer arms composed of oligo(ethylene glycol) methyl ether acrylate (OEGA) and acrylic acid (AA) has been synthesized for the first time. This star block copolymer showed a spherical morphology with an average diameter of 62 nm and rapidly formed a hydrogel in normal saline under physiological conditions when it was mixed with Ca²⁺. Furthermore, the star block copolymer and its hydrogel cross-linked by Ca²⁺ showed excellent biocompatibility both in vitro and in vivo.