Schulzeines A-C, New -Glucosidase Inhibitors from the Marine Sponge Penares schulzei1
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- 作者：Kentaro Takada ; Taisuke Uehara ; Yoichi Nakao ; Shigeki Matsunaga ; Rob W. M. van Soest ; and Nobuhiro Fusetani
- 刊名：Journal of the American Chemical Society
- 出版年：2004
- 出版时间：January 14, 2004
- 年：2004
- 卷：126
- 期：1
- 页码：187 - 193
- 全文大小：167K
- 年卷期：v.126,no.1(January 14, 2004)
- ISSN：1520-5126
文摘
Three new 
-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marinesponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradationsto be the isoquinoline alkaloids, encompassing two amino acids, and C28 fatty acid, the last of which wassulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosheranalysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit -glucosidase with IC50values of 48-170 nM.
-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marinesponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradationsto be the isoquinoline alkaloids, encompassing two amino acids, and C28 fatty acid, the last of which wassulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosheranalysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit -glucosidase with IC50values of 48-170 nM.