Regioselective Synthesis of Multisubstituted Benzenes by Palladium-Catalyzed Intermolecular Reaction of 尾-Iodo-尾-silylstyrenes with Alkynes

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• 作者：Hidenori Kinoshita ; Hirotoshi Takahashi ; Katsukiyo Miura
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 21, 2013
• 年：2013
• 卷：15
• 期：12
• 页码：2962-2965
• 全文大小：251K
• 年卷期：v.15,no.12(June 21, 2013)
• ISSN：1523-7052

文摘

The Pd-catalyzed reaction between 尾-iodo-尾-silylstyrenes and terminal alkynes in i-Pr₂NEt gave 1,2,3,5-tetrasubstituted benzenes with complete regioselection. The use of certain silylacetylenes as alkynes enabled efficient synthesis of 1,3,5-trissilyl-2-arylbenzenes, which could be transformed into other multisubstituted benzenes by displacement of the silyl groups.