Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives
详细信息 查看全文
- 作者：Tomoaki Hirata ; Isao Takahashi ; Yuya Suzuki ; Hiroaki Yoshida ; Hiroshi Hasegawa ; Osamu Kitagawa
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：January 4, 2016
- 年：2016
- 卷：81
- 期：1
- 页码：318-323
- 全文大小：377K
- ISSN：1520-6904
文摘
N-C axially chiral phenanthridin-6-one derivatives bearing various ortho-substituted phenyl groups on the nitrogen atom were enantioselectively prepared through (R)-DTBM-SEGPHOS-Pd(OAc)2-catalyzed intramolecular Buchwald–Hartwig amination. The enantioselectivity strongly depended on solvents, bases, and reaction temperature as well as on the bulkiness of ortho-substituents.