Effective Method To Remove Metal Elements from Pharmaceutical Intermediates with Polychelated Resin Scavenger

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• 作者：Hidetoshi Miyamoto ; Chihiro Sakumoto ; Eriko Takekoshi ; Yukiko Maeda ; Narumi Hiramoto ; Takahiro Itoh ; Yoshiaki Kato
• 刊名：Organic Process Research & Development
• 出版年：2015
• 出版时间：August 21, 2015
• 年：2015
• 卷：19
• 期：8
• 页码：1054-1061
• 全文大小：385K
• ISSN：1520-586X

文摘

A catalytic reaction is an important methodology for the production of pharmaceuticals from the viewpoint of green and sustainable chemistry. Since elemental impurity levels should be controlled within acceptable limits in API, the development of removal of element is also important as well. The technology for removal of elements was developed using cost-effective polychelated resin scavenger. The precious elements were removed efficiently by passing through the packed cartridge filled with appropriate scavenger. The feasibility of the scavenger was evaluated, and the application for actual manufacturing process is described. In contrast to another type of immobilized scavengers, polychelated resin scavenger provides an inexpensive method to scavenge several elements.