Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei
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- 作者：Shu Nishikori ; Kenji Takemoto ; Shinji Kamisuki ; Syo Nakajima ; Kouji Kuramochi ; Senko Tsukuda ; Masashi Iwamoto ; Yuri Katayama ; Takahiro Suzuki ; Susumu Kobayashi ; Koichi Watashi ; Fumio Sugawara
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：February 26, 2016
- 年：2016
- 卷：79
- 期：2
- 页码：442-446
- 全文大小：326K
- ISSN：1520-6025
文摘
New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A–C (1–3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), and herqueinone/isoherqueinone (7/7a), were also obtained. The isolated compounds were tested for anti-hepatitis C virus (HCV) activity, and peniciherquamide C (3) was found to display an IC50 value of 5.1 μM. To our knowledge, this is the first report of a diazabicyclo[2.2.2]octane derivative with anti-HCV activity.