Dynamics and Thermodynamics of Dimerization of Parallel G-Quadruplexed DNA Formed from d(TTAGn) (n = 3-5)

详细信息    查看全文

• 作者：Yoshitake Kato ; Takako Ohyama ; Hajime Mita ; and Yasuhiko Yamamoto
• 刊名：Journal of the American Chemical Society
• 出版年：2005
• 出版时间：July 20, 2005
• 年：2005
• 卷：127
• 期：28
• 页码：9980 - 9981
• 全文大小：74K
• 年卷期：v.127,no.28(July 20, 2005)
• ISSN：1520-5126

文摘

Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAG_n), where n = 3-5, have been shown to form a dimer through end-to-end stacking of 3'-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of ~1 s^-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin.